Tubularized urethral reconstruction using everted saphenous vein graft in a beagle model

نویسندگان

چکیده

Abstract Background A long segment stricture in the anterior urethra is a challenge urology. We conducted study to investigate efficacy of urethral reconstruction using an everted saphenous vein graft (SVG) tubular fashion. Methods Twelve male beagles were randomly divided into three groups: experimental group (n = 5), control 5) and normal 2). 3 cm defect was created. Autologous SVG harvested. In group, replaced by performed uneverted SVG. Beagles all groups received retrograde urethrography evaluate patency killed for histological examination 6 months after operation. Results Four had no voiding difficulty other one could not void spontaneously. Retrograde showed four wide lumens. Ether or fistula detected animals group. Histological analysis indicated completely integrated urethra. The reconstructed contained lumen covered urothelium. periurethral collagen muscle fibers formed highly organized. Everted high ability neovascularization. fibrotic where urothelium intact. Only few new capillaries formed. Conclusions demonstrates promising strategy potential repair.

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ژورنال

عنوان ژورنال: BMC Urology

سال: 2021

ISSN: ['1471-2490']

DOI: https://doi.org/10.1186/s12894-021-00833-4